Posted by elisa on April 15, 2013 at 8:57am in Main
Ciao a tutti. Ho una bellissima notizia che accende le speranze per una giarigione a breve della vitiligine. Un mio amico di facebook, un dermatologo ricercatore italiano, il dott. Matteo Bordignon, attraverso i suoi studi sulla vitiligine durati cinque anni, avrebbe scoperto la vera causa e patogenesi della vitiligine. Entro il mese prossimo i suoi studi saranno pubblicati su una importante rivista dermatologica di fama mondiale.
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Ciao, Elisa. Is there anything you can tell us about what Bordignon is going to say about Vitiligo? Do you know what his basic conclusions are? Thanks, Joe
Ciao, Elisa. C'è qualcosa che puoi dirci a cosa Bordignon sta per dire di vitiligine? Sapete quali sono le sue conclusioni di base sono? Grazie, Joe
I read the link you provided and here is what seems to be a relevant excerpt from the data. It underscores what most people say, that treatment and response varies greatly with everyone:
"Several therapies can be considered in treatment of vitiligo (Sehgal VN, Srivastava G. Vitiligo treatment options: an evolving scenario. J Dermatolog Treat 2006; 17: 262-75). None of the single vitiligo therapies produces predictably good results in all patients; the response to single therapy is highly variable. Generally, the treatment must be individualized, and patients should be made aware of the risks associated with therapy. The most common treatments for non-segmental vilitigo are:
- Narrow-Band Ultra Violet B (UVB-NB) phototherapy: widely used with good clinical results, based on narrow-band fluorescent tubes with an emission spectrum of 310-315 nm and a maximum wavelength of 31 1 nm. Treatment frequency is 2-3 times weekly, but never on consecutive days. This treatment can be safely used in children, pregnant women, and lactating women. Short-term adverse effects include pruritus and xerosis. Long-term adverse effects are not well defined since the carcinogenic potential of UVB is still to be clarified. The therapy achieved the best results on vitiligoid patches of face and trunk; very poor results usually are achieved on vitiligo of hands and feet.
- Corticosteroid therapy: corticosteroids are used topically, systemically o intralesionally; topical steroids are often chosen first to treat localized vitiligo but the results of therapy have been reported as moderately successful, particularly in patients with localized vitiligo and/or an inflammatory component to their vitiligo, even if the inflammation is subclinical. The use of topic, systemic or intra-lesional steroids may have side effects like toxicity (systemic) or cutaneous atrophy (topical or intra-lesional); in addiction very poor results usually are achieved on vitiligo of hands and feet.
- Topical calcineurin inhibitors (tacrolimus and pimecrolimus): tacrolimus and pimecrolimus could be successful used to cure vitiligoid patches of face and neck; recently, Food and Drug Administration (FDA) imposed a "black box warning" on the topical calcineurin inhibitors, because of a theoretic risk of oncogenesis because of the trivial systemic absorption of these agents; in addiction very poor results usually are achieved on vitiligo of hands and feet. Surgical alternatives exist for the treatment of vitiligo; however, because of the time- consuming nature of surgical therapies, these treatment regimens are limited to segmental or localized vitiligo.
So far, anyway, none of these therapies could reach a complete re-pigmentation of the vitiliginous patches in all the patients.
The precise mechanism of action of these therapies is still unknown and it is generically attributed to their immunosuppressive activity. It is remarkable, however, that UVB-NB radiation increase alpha5beta1 integrin expression on melanocytes after exposure (Neitmann M, Alexander M, Brinckmann J, Schlenke P, Tronnier M. Attachment and chemotaxis of melanocytes after ultraviolet irradiation in vitro. Br J Dermatol 1999; 141: 794-801)."
Azr Khatana > Steve HargadonApril 19, 2013 at 3:04am
I think the following diagram may help the mechanism of MIA that is only found in vitiligo patient.
Figure 1 shows the mechanism of action of alpha5beta1 integrin and MIA in melanocytes leading to vitiligo. In panel A the normal adhesion of melanocyte with the basal membrane, mediated by alpha5beta1 integrins is shown. In panel B a vitiligious melanocyte attacked by MIA, which binds to alpha5beta1 integrins, is shown. In panel C: it is shown that, after the binding of MIA with alpha5beta1 integrins, the presence of other precipitating factors as oxidative stress, physical trauma or autoantibodies lead to a partial detachment of the melanocyte. In panel D the complete detachment of melanocyte and formation of vitiligoid patches on the skin (melanocytorrhagy) is shown. In panel E an anti- MIA drug binding to MIA and inactivating it is shown. In panel F the vitiliginous melanocyte keeping the adhesion with the basal membrane even in the presence of precipitating factors is shown.
I never thought otherwise, the autoimmunity theory is a situped one.
This work seems to be an important one dealing with the lime wash/wall painting. Of course it shoud not be considered as a total solution to vit, because everybody is different (physically, biochemically, etc). But when you want pigments, you can get it for some time. It is not bad at all.
This was the thing all other medical companies are asking for. If other medical companies knew the real concrete universal solution, it is better for them to release. It is a good time for them, since they are not going to money out of it.
After this study will be publish on Journal of dermatological science, a free forum on facebook will be open. In this forum everybody can partecipate and ask for everything you will know about this important discovery.
Replies
Ciao, Elisa.
Is there anything you can tell us about what Bordignon is going to say about Vitiligo? Do you know what his basic conclusions are?
Thanks, Joe
Ciao, Elisa.
C'è qualcosa che puoi dirci a cosa Bordignon sta per dire di vitiligine? Sapete quali sono le sue conclusioni di base sono?
Grazie, Joe
I don't fully understand the following, but it seems to be a pretty detailed description (scroll down) of this research.
http://www.sumobrain.com/patents/wipo/Mia-melanoma-inhibitory-activ...
Steve, hi,
I read the link you provided and here is what seems to be a relevant excerpt from the data. It underscores what most people say, that treatment and response varies greatly with everyone:
"Several therapies can be considered in treatment of vitiligo (Sehgal VN, Srivastava G. Vitiligo treatment options: an evolving scenario. J Dermatolog Treat 2006; 17: 262-75). None of the single vitiligo therapies produces predictably good results in all patients; the response to single therapy is highly variable. Generally, the treatment must be individualized, and patients should be made aware of the risks associated with therapy. The most common treatments for non-segmental vilitigo are:
- Narrow-Band Ultra Violet B (UVB-NB) phototherapy: widely used with good clinical results, based on narrow-band fluorescent tubes with an emission spectrum of 310-315 nm and a maximum wavelength of 31 1 nm. Treatment frequency is 2-3 times weekly, but never on consecutive days. This treatment can be safely used in children, pregnant women, and lactating women. Short-term adverse effects include pruritus and xerosis. Long-term adverse effects are not well defined since the carcinogenic potential of UVB is still to be clarified. The therapy achieved the best results on vitiligoid patches of face and trunk; very poor results usually are achieved on vitiligo of hands and feet.
- Corticosteroid therapy: corticosteroids are used topically, systemically o intralesionally; topical steroids are often chosen first to treat localized vitiligo but the results of therapy have been reported as moderately successful, particularly in patients with localized vitiligo and/or an inflammatory component to their vitiligo, even if the inflammation is subclinical. The use of topic, systemic or intra-lesional steroids may have side effects like toxicity (systemic) or cutaneous atrophy (topical or intra-lesional); in addiction very poor results usually are achieved on vitiligo of hands and feet.
- Topical calcineurin inhibitors (tacrolimus and pimecrolimus): tacrolimus and pimecrolimus could be successful used to cure vitiligoid patches of face and neck; recently, Food and Drug Administration (FDA) imposed a "black box warning" on the topical calcineurin inhibitors, because of a theoretic risk of oncogenesis because of the trivial systemic absorption of these agents; in addiction very poor results usually are achieved on vitiligo of hands and feet. Surgical alternatives exist for the treatment of vitiligo; however, because of the time- consuming nature of surgical therapies, these treatment regimens are limited to segmental or localized vitiligo.
So far, anyway, none of these therapies could reach a complete re-pigmentation of the vitiliginous patches in all the patients.
The precise mechanism of action of these therapies is still unknown and it is generically attributed to their immunosuppressive activity. It is remarkable, however, that UVB-NB radiation increase alpha5beta1 integrin expression on melanocytes after exposure (Neitmann M, Alexander M, Brinckmann J, Schlenke P, Tronnier M. Attachment and chemotaxis of melanocytes after ultraviolet irradiation in vitro. Br J Dermatol 1999; 141: 794-801)."
I think the following diagram may help the mechanism of MIA that is only found in vitiligo patient.
http://patentscope.wipo.int/search/docservice_fpimage/WOIB201205114...
Figure 1 shows the mechanism of action of alpha5beta1 integrin and MIA in melanocytes leading to vitiligo. In panel A the normal adhesion of melanocyte with the basal membrane, mediated by alpha5beta1 integrins is shown. In panel B a vitiligious melanocyte attacked by MIA, which binds to alpha5beta1 integrins, is shown. In panel C: it is shown that, after the binding of MIA with alpha5beta1 integrins, the presence of other precipitating factors as oxidative stress, physical trauma or autoantibodies lead to a partial detachment of the melanocyte. In panel D the complete detachment of melanocyte and formation of vitiligoid patches on the skin (melanocytorrhagy) is shown. In panel E an anti- MIA drug binding to MIA and inactivating it is shown. In panel F the vitiliginous melanocyte keeping the adhesion with the basal membrane even in the presence of precipitating factors is shown.
Ciao Elisa,
Leggi tu messagio. Comprendo que un dermatologo italiano ha descubierto la vera causa della vitiligine.
Vorei liggere la rivista dermatologica, per favore.Puoi inserire nel sito VF;
Grazie mile.
Excusi por mi italiano. Comprendo, parlo poco.
SYLVIA
Mr Pessimistic says,
I never thought otherwise, the autoimmunity theory is a situped one.
This work seems to be an important one dealing with the lime wash/wall painting. Of course it shoud not be considered as a total solution to vit, because everybody is different (physically, biochemically, etc). But when you want pigments, you can get it for some time. It is not bad at all.
This was the thing all other medical companies are asking for. If other medical companies knew the real concrete universal solution, it is better for them to release. It is a good time for them, since they are not going to money out of it.
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