Vitiligo International Symposium in Rome (updates)

Dear Friends,

As promissed, I have some updates about the symposium in Rome. Dr. Matteo Bordignon presented his research and his current experiment:

1- As you know, his hyphotesis is that MIA presence is the cause of vitiligo;

2- He has already collected some epidermis from vitiligo volunteer's patches and confirmed its presence;

3- A known laboratory has also confirmed MIA presence in vitiligo patches as counter-proof;

4- He worked on an animal model, by injecting MIA in some mice tails. Guess what happened? He induced vitiligo in these mice.

5-Different from Caroline Le Poole that ordered genetic modified mice from a lab (with white patches - maybe not vitiligo) and reverted it by undoing the modification, Dr. Bordignon used ordinary mice. He injected MIA (his hyphotesis) in their tails for a short term and it caused vitiligo;

6- His theory is based on the fact that vitiligo sufferer's produce MIA by default, when skin is submited to pressure, friction and oxidative stress;

7-MIA is a protein that should be only produced by melanomas, other than melanocytes. MIA was found by a German scientist. Dr. Bordignon only found the role of this protein as an agent that causes vitiligo. His hyphotesis has been confirmed by this animal model.

8- See the pictures below:

Risultati preliminari=Preliminary results

Iniezione di proteina MIA=Injections of MIA protein

Prima=Before

Dopo=After

9- These pictures made finally the scientific community start taking in consideration that MIA might be the agent that causes vitiligo. i personally believe so.

Regards,

Flavio

I think the most complete research is the one by Fukunaga. He considers that melanocytes have 2 adhesion mechanisms (integrins and matricelular proteins). I like the way he approaches, since besides integrin (main mechanism), he considers only CCN matricelular protein as a contingent adhesion mechanisms. He believes that proteins like thrombospondin, osteopontin, osteonectin/SPARC, tenascin, disintegrins, galectins, etc. may play a role in the adhesion mechanism, but not unique as CCN3 that interacts with collagen IV.

I also like the Dr. Bordignon's approach, because it's very simplified and pragmatic. He only considers integrin as a relevant adhesion mechanism. I think it works, because vitiligo sufferers might have the contingent mechanism faulty indeed.

I didn't go very deep inside Dr. Wagner RY's theory, because I think that besides e-cadherin has been studied by many researchers as an adhesion mechanism, it has not led to any concrete result..

Bottom line:

I don't think researchers want to work together, what really bothers me. I really think they want to keep their "status quo" like I said before. I hope I'm wrong.

I like Dr. Bordignon's style, since he doesn't do research for a living. He does it for passion.

Replies

Saurabh Misra January 1, 2017 at 3:09pm

Ok. You are right then.
So this property of MIA protein was discovered in 2003 by Anja-Katrin Bosserhoff and others.
So two simultaneous studies are going involving MIA protein and E-Cadherin wrt to cell adhesion theory in Vitiligo one led by Dr Bordignon and one led by Dr Wagner.
Dr Wagner study has not taken Dr Bordignon's study into consideration.
- Robot > Saurabh Misra January 1, 2017 at 3:12pm
  
  There is another one by Mizuho Fukunaga...
  - Saurabh Misra > Robot January 1, 2017 at 4:56pm
    
    Can we reconcile the theories of Dr Wagner and Dr Bordinon wrt to Melanocytes detachment. The first one seems to suggest that this detachment due to ECadherin is present before and after onset of Vitiligo while in the latter samples of pre- existing vitiligo skin I.e after onset were taken and found to be caused by presence of MIA protein.
    However, they both have a long way to go still.
    Judging the safety of their would be treatments is a bit premature.
    Because they themselves have to judge it first.
    I agree Dr Bordignon seems to be one step ahead of Dr Wagner. Both are however approaching the same thing from different directions.
    Either both theories will fall by the side, both will go together, or only one will succeed... With or without using other theories.
    My view is that in 2-3 years time with more research taking place good parts all the theories (mutation, adhesion, oxidative stress) will merge and a good answer will come out because these researchers are holding joint seminars and trying to come to a solution. They have even published study papers giving a cumulative view of the pathogenesis in Vitiligo.
    - Robot > Saurabh Misra January 1, 2017 at 6:15pm
      
      Last but not least, I'd love to see Dr. Bordignon sharing data with Fukunaga, supervised by Anja.
      - Robot > Robot January 1, 2017 at 6:34pm
        
        But it's not gonna happen...
        
        Saurabh Misra > Robot January 2, 2017 at 2:19pm
        
        Genetic Mutation and Cell Adhesion theories may be related and can be reconciled.
        Presence of MIA protein in Vit skin can be due genetic mutation otherwise why it's there?
        Various molecules are responsible for Cellular Adhesion mechanism.
        In this Indian study genetic mutation as well as over expression of intercellular adhesion molecule 1 (ICAM1) were found to be associated with Vitiligo.
        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842287/?tool=pmcentrez
        
        Robot > Saurabh Misra January 2, 2017 at 3:45pm
        
        I guess it's a genetic issue. For any reason when the faulty contingent adhesion mechanism acts, it generates MIA instead of other matricelular protein.
        
        Saurabh Misra > Saurabh Misra January 2, 2017 at 3:02pm
        
        Flavio, I noticed one thing in the patent review paper cited by DJ.
        The authors are all Brazilian. You are Brazilian too.
        Dr Bordignon has good Brazilian support when it comes to his research relating to MIA protein.
    - Robot > Saurabh Misra January 1, 2017 at 6:09pm
      
      I think the most complete research is the one by Fukunaga. He considers that melanocytes have 2 adhesion mechanisms (integrins and matricelular proteins). I like the way he approaches, since besides integrin (main mechanism), he considers only CCN matricelular protein as a contingent adhesion mechanisms. He believes that proteins like thrombospondin, osteopontin, osteonectin/SPARC, tenascin, disintegrins, galectins, etc. may play a role in the adhesion mechanism, but not unique as CCN3 that interacts with collagen IV.
      
      I also like the Dr. Bordignon's approach, because it's very simplified and pragmatic. He only considers integrin as a relevant adhesion mechanism. I think it works, because vitiligo sufferers might have the contingent mechanism faulty indeed.
      
      I didn't go very deep inside Dr. Wagner RY's theory, because I think that besides e-cadherin has been studied by many researchers as an adhesion mechanism, it has not led to any concrete result..
      
      Bottom line:
      
      I don't think researchers want to work together, what really bothers me. I really think they want to keep their "status quo" like I said before. I hope I'm wrong.
      
      I like Dr. Bordignon's style, since he doesn't do research for a living. He does it for passion.
      - Saurabh Misra > Robot January 3, 2017 at 4:51pm
        
        This Flavio son of a bitch has also written 4 fake review papers as submitted by D J
        http://ufrj.academia.edu/FLAVIOCORAGEM

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