To all,

I do not come onto this forum often. Some of you may know that my research team at the University of Colorado has been researching the genetic basis of vitiligo for almost 20 years, and we have made outstanding progress. Our findings have been published in some of the world's leading medical journals.

We are in now completing a third major phase of the research project. We already know this phase will dramatically expand what we know about vitiligo, quite possibly leading to genetic tests for vitiligo susceptibility in patients' relatives, identify biological subtypes of vitiligo that may allow more targeted treatment to specific patients, and likely will provide new insights that will enable new approaches to treatment.

However, we still need a few additional study participants, and we basically need folks to participate right now. Participation is quite easy and costs nothing. All you need to do is fill out the study entry questionnaire posted on the Vitiligo Friends site (http://www.vitiligofriends.org/forum/topics/vitiligo-genetic-studies-participants-needed), save it, and mail or email it to me at the addresses provided on the form. We will then send you official study forms, a saliva sampling kit, and a prepaid return mailer. Ideally, you would also recruit an unrelated non-vitiligo "control" subject for your sample.  All of your study data remain confidential; unfortunately, we are not permitted to return individual-level study data to participants. 

The current phase of the study is only open to Caucasians in the USA and Canada. This phase of the study will close in the next few months. If you have never participated in our studies and submitted a sample, please consider doing so now.  It will make a difference. 

With thanks in advance,

Richard A. Spritz, M.D.

richard.spritz@ucdenver.edu 

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  • Dear Dr.Spritz ,glad you join this Group ,I hope you will find many who will participate in your researches ,there were a time we felt you are the one who will help us , it took long time .I hope you will find soon the possible gene which cause vitiligo and lead you to some treatment.


    I advice you to join facebook Groups called "Vitiligo" and "The vitiligo society" in UK  they have several members.

    What do you think about the MIA theory?

    Bamsegutt

  • We have received your kit and will be sending our samples this week. 

    Where have your research results so far been published?

    Many thanks for doing this!

    • We have published literally dozens of papers. I suggest you search at http://www.ncbi.nlm.nih.gov/pubmed

      • Can you send the links specifically?  Which ones do you suggest for reading?

          • I like the second paper, when it says: "...points to an apparent inverse relationship between susceptibility to GV versus malignant melanoma, suggesting that GV may result, in part, from dysregulation of normal processes of immune surveillance against melanoma"

            In other words, this is what Dr. Matteo Bondignon simplifies saying that the same mechanism that detaches malignant melanoma is the one observed in vitiligo sufferers.  The same protein (MIA) produced by malignant melanoma to cause metastasis, is the one that detaches non-malignant melanocytes causing vitiligo.  It converges...

            The big difference is that the expression "dysregulation of immune surveillance against melanoma" is typical when some mechanism is not known.  It's easy to blame the immune system, but,  as a matter of fact, it's the one that protects our body.  Dr. Matteo Bordignon was able to find out the role of MIA in vitiligo. He was able to identify the real cause of disappearance  of melanocyte without blaming the immune system.  It's hard for any researcher that didn't have this insight to accept this new paradigm.  

            Melanocytes are detached from the basal membrane of vitiligo sufferer's skin because of non-malignant  (but dysfunctional)  melanocytes produce MIA (melanoma inhibitory activity) wrongly.  That's the real reason.  These melanocytes migrate to the outer layer of the skin and exfoliate without being killed.  MIA destroys the melanocyte's connection to fibronectin, called alpha5 beta1 integrins, what let them go away...

          • Thanks!

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