From my experience, I can say that Ayurveda Treatments for Vitiligo is the best way to cureVitiligo. Traditional Ayurveda can control the patches without any side effects. And the medicines are completely extracted from natural ingredients.Padanjali Ayurvedics is an exclusive Skin Treatment Centre located at Kuttipuram in Malappuram district of Kerala. You can consult the Ayurveda doctor here and know the details.
Existing treatments such as topical steroids and light therapy, which are used “off-label” because they have not been FDA-approved to treat vitiligo, can be effective for patients. These treatments reverse the disease by stimulating brown spots to appear around hair follicles within the affected white patches of skin. As these brown spots increase in number and size they merge until the white patch is replaced with normal skin color.
Current treatments for vitiligo involve stimulating pigment cell regrowth from the hair follicles, which results in brown dots around the hairs. As these brown dots grow and merge, the white patches disappear.John Harris
This takes between one and two years, depending on the location of the body being treated. However, in most cases the white spots reappear at the same location, often within just one year after stopping the treatments. This recurrence can be just as devastating as when the white patches first appeared.
We wanted to find out why these spots reappear. Our research team suspected that “memory” forms within the skin when the white spots first appear, so that the spots “know” where to return when treatments are stopped. Working separately, we and three other laboratories led byLiv Eidsmo,Mary Jo Turk, andJulien Seneschalsearched for the source of this memory in the skin.
Thesethreeotherlabsfirst found cells in vitiligo skin from mice or humans that looked a lot like the memory cells that protect the skin from a second exposure to a viral infection, suggesting that the body “thinks” it is fighting a viral infection when it “misfires” at the patient’s normal cells, killing the pigment-producing cells in the skin called melanocytes and causing vitiligo. These cells are called “resident memory T cells.”
Because immune responses to a virus act in a similar way to immune responses that cause autoimmune diseases, it seemed reasonable that these cells might also be the source of this remaining disease memory in the skin.
Disease memory can be erased with new treatment
We used a technique calledskin blisteringto isolate skin and skin fluid directly from the spots of my vitiligo patients and isolate the disease-causing memory cells so we could analyze them more closely. Similar to the other labs, we also found the virus-like memory cells, and we were able to also determine that these cells specifically targeted the melanocytes. We hypothesized that if we could remove these memory cells from the skin using a new treatment, then treatments to repigment the skin would be long-lasting and possibly permanent.
We then tested our hypothesis on mice we specifically engineered to develop vitiligo. Like humans, mice also have memory T-cells so we looked for their “Achilles heel” to see if we could knock them out without harming other cells. Our team figured out that the vitiligo-causing memory cells require a special protein called “IL-15” to survive. We injected the vitiligo mice with an antibody that blocks the IL-15 protein from interacting with the memory cells.
After just a few weeks wediscoveredthat the treatment wiped out the memory cells from the mouse skin, allowing the brown pigment to return in a spotty pattern, just as we see in patients who respond to therapy. Importantly, just two weeks of antibody treatments caused repigmentation that lasted for months, suggesting this strategy, unlike existing treatments, might provide long-term benefit for vitiligo patients.
On the left is a mouse with vitiligo that received control antibody. After 12 weeks the tail remained white, without pigment. The mouse on the right also had vitiligo but was treated with the antibody to block IL-15 signaling. Twelve weeks later the tail was largely repigmented.John Harris
Human clinical trials may begin next summer
During our study we also found that the vitiligo-causing memory T-cells in both mouse and human skin seem to require IL-15 more than other types of T cells – which means they are more sensitive to levels of this protein. This is important because it means we might be able to selectively remove the vitiligo-causing cells without harming other important immune cells too. In the treated mice, the vitiligo-causing cells became undetectable, but the other T-cells responsible for fighting infection remained unharmed and present, suggesting that our antibody therapy might be safer for the immune system than first thought.
Based on these results, we are working with the National Institutes of Health-fundedImmune Tolerance Network(ITN) to develop aclinical trialto test this antibody treatment in human patients. We are hopeful that we can begin recruiting patients next summer.
Although this antibody drug has only been proven to work in mice with vitiligo, we are excited totest it in humansbecause it could represent a significant advance over existing treatments. The partnership with the ITN will allow us not only to test whether it works for vitiligo patients, but also how it works. This will help us know when and in whom to use this new therapy.
dorothy > Adam RzepeckiSeptember 15, 2018 at 7:24pm
The vitiligo on face is easy to cure ,it need about 3-6months .the vitiligo on body need about 6-9months to cure .the vitiligo on feet and finger need about one year to cure totally.
Replies
From my experience, I can say that Ayurveda Treatments for Vitiligo is the best way to cureVitiligo. Traditional Ayurveda can control the patches without any side effects. And the medicines are completely extracted from natural ingredients.Padanjali Ayurvedics is an exclusive Skin Treatment Centre located at Kuttipuram in Malappuram district of Kerala. You can consult the Ayurveda doctor here and know the details.
Your skin has a memory
Existing treatments such as topical steroids and light therapy, which are used “off-label” because they have not been FDA-approved to treat vitiligo, can be effective for patients. These treatments reverse the disease by stimulating brown spots to appear around hair follicles within the affected white patches of skin. As these brown spots increase in number and size they merge until the white patch is replaced with normal skin color.
Current treatments for vitiligo involve stimulating pigment cell regrowth from the hair follicles, which results in brown dots around the hairs. As these brown dots grow and merge, the white patches disappear. John Harris
This takes between one and two years, depending on the location of the body being treated. However, in most cases the white spots reappear at the same location, often within just one year after stopping the treatments. This recurrence can be just as devastating as when the white patches first appeared.
We wanted to find out why these spots reappear. Our research team suspected that “memory” forms within the skin when the white spots first appear, so that the spots “know” where to return when treatments are stopped. Working separately, we and three other laboratories led by Liv Eidsmo, Mary Jo Turk, and Julien Seneschal searched for the source of this memory in the skin.
These three other labs first found cells in vitiligo skin from mice or humans that looked a lot like the memory cells that protect the skin from a second exposure to a viral infection, suggesting that the body “thinks” it is fighting a viral infection when it “misfires” at the patient’s normal cells, killing the pigment-producing cells in the skin called melanocytes and causing vitiligo. These cells are called “resident memory T cells.”
Because immune responses to a virus act in a similar way to immune responses that cause autoimmune diseases, it seemed reasonable that these cells might also be the source of this remaining disease memory in the skin.
Disease memory can be erased with new treatment
We used a technique called skin blistering to isolate skin and skin fluid directly from the spots of my vitiligo patients and isolate the disease-causing memory cells so we could analyze them more closely. Similar to the other labs, we also found the virus-like memory cells, and we were able to also determine that these cells specifically targeted the melanocytes. We hypothesized that if we could remove these memory cells from the skin using a new treatment, then treatments to repigment the skin would be long-lasting and possibly permanent.
We then tested our hypothesis on mice we specifically engineered to develop vitiligo. Like humans, mice also have memory T-cells so we looked for their “Achilles heel” to see if we could knock them out without harming other cells. Our team figured out that the vitiligo-causing memory cells require a special protein called “IL-15” to survive. We injected the vitiligo mice with an antibody that blocks the IL-15 protein from interacting with the memory cells.
After just a few weeks we discoveredthat the treatment wiped out the memory cells from the mouse skin, allowing the brown pigment to return in a spotty pattern, just as we see in patients who respond to therapy. Importantly, just two weeks of antibody treatments caused repigmentation that lasted for months, suggesting this strategy, unlike existing treatments, might provide long-term benefit for vitiligo patients.
On the left is a mouse with vitiligo that received control antibody. After 12 weeks the tail remained white, without pigment. The mouse on the right also had vitiligo but was treated with the antibody to block IL-15 signaling. Twelve weeks later the tail was largely repigmented. John Harris
Human clinical trials may begin next summer
During our study we also found that the vitiligo-causing memory T-cells in both mouse and human skin seem to require IL-15 more than other types of T cells – which means they are more sensitive to levels of this protein. This is important because it means we might be able to selectively remove the vitiligo-causing cells without harming other important immune cells too. In the treated mice, the vitiligo-causing cells became undetectable, but the other T-cells responsible for fighting infection remained unharmed and present, suggesting that our antibody therapy might be safer for the immune system than first thought.
Based on these results, we are working with the National Institutes of Health-funded Immune Tolerance Network (ITN) to develop a clinical trial to test this antibody treatment in human patients. We are hopeful that we can begin recruiting patients next summer.
Although this antibody drug has only been proven to work in mice with vitiligo, we are excited to test it in humans because it could represent a significant advance over existing treatments. The partnership with the ITN will allow us not only to test whether it works for vitiligo patients, but also how it works. This will help us know when and in whom to use this new therapy.
Is this real??? Someone???
How long took the treatment?
The vitiligo on face is easy to cure ,it need about 3-6months .the vitiligo on body need about 6-9months to cure .the vitiligo on feet and finger need about one year to cure totally.