I thought Th17 is inducing autoimmunity but on the other hand Th17 produce IL-10, IL-22 cytokines which inhibits autoimmune disease, and Tregs induce Th17 by producing TGF beta, while Tregs inhibit Th1 which inhibit Th17 cells, and Th1 inhibit Cancer so that means we don't get cancer!! all these guys are swords with 2 edges. because we are all different genetically and these cytokines produced when specific genes are on or off, so for e.g. an unknown antigen can switch Tregs genes on to produce cytokines to induce Th17 then attach melanocytes!! then get Vitiligo!! what balance can we have for this? Natural or Immunotherapy? I put few video up please look at them and see what these Dr's say ?
You need to be a member of Vitiligo Friends to add comments!
Replies
Th17 has 2 subsets:
Effector Th17 and the Regulator Th17
It is interesting that you brough about Th17 thory, there are a groupp of sientistis in Japan reaserching for many years about the link between Kertatinocyte PSTAT3 and Th17 cell infiltration in Vitiligo skin.It has been dicussed in Milano world vitiligo congress..they are clouse to know ,we hope to hear the resent news soon,
Professor Spritz and his groupp has confrmed that we vities have less chance of developing the worest skin cancer called Melanoma.The anti body which attaccs the melanocyte defend us from skin cancer as well.
Bamsegutt
I was just looking at some papers, saying that "chang shan " the chines herb is suppressing the effector Th17, without suppressing any other T helper cells. "For roughly two thousand years, Chinese herbalists have treated Malaria using a root extract, commonly known as Chang Shan, from a type of hydrangea that grows in Tibet and Nepal. More recent studies suggest that halofuginone, a compound derived from this extract's bioactive ingredient, could be used to treat many autoimmune disorders as well. Now, researchers from the Harvard School of Dental Medicine have discovered the molecular secrets behind this herbal extract's power. It turns out that halofuginone (HF) triggers a stress-response pathway that blocks the development of a harmful class of immune cells, called Th17 cells, which have been implicated in many autoimmune disorders.
"HF prevents the autoimmune response without dampening immunity altogether," said Malcolm Whitman, a professor of developmental biology at Harvard School of Dental Medicine and senior author on the new study. "This compound could inspire novel therapeutic approaches to a variety of autoimmune disorders."