NSV (Genetic Predisposition x Cause x Trigger x Untrigger x Cure)

Hi Friends,

I would like to share with you some concepts that I've been thinking about, so that any feedback would be very welcome to improve my constant amateur research about NSV (non-segmental vitiligo).

GENETIC PREDISPOSITION: I believe it plays the major role in vitiligo. It's a genetic predisposition of having dysfunctional melanocyte adhesion. Either by inheritance or fetal DNA formation.

The one who has it, becomes in constant NSV potential status.

CAUSES (Physical, Emotional, Psychological and Environmental):

1) Systematic physical traumas (friction, injuries, itches, scratches, allergies, sun burns, impacts, violent moves, and others).

2) Oxidative stress (excess of free radicals). It's a complex concept that can be reached by many ways. The major ones are: food allergy, poor diet, leaky gut and dysbiosis (parasites, candida, h-pylori, yeast, fungus, etc.).

3) Stress hormones generated by psychological and emotional systematic stress (for example: if you are a person who is feeling completely out of place, you feel that you are no one in the group or you have no sense of belonging; if you are a ”yes-but” person and are never satisfied with what you have, how you look or what you are; if you feel that there is lack of joy in your life; etc.).

4) Exceptional causes: There are exceptional causes like hypothyrodism, Hashimoto disease, adrenal fatigue, liver toxicity, lead contamination, and others that might be correlated to vitiligo, to which check must be addressed before starting any treatment plan. They are usually linked to different types of vitiligo, other than NSV.

TRIGGER: Trigger is the one that makes the genetic predisposition wake up. It only works if one or more causes above are present (usually they are in any person).

Although it varies from person to person, it has the following facets: emotional, psychological, physical and environmental. Whatever the trigger type is, it's always a severe trauma. Stress hormones play a big role in triggering vitiligo, what makes emotional and psychological trigger facets the most relevant ones. Some trigger examples are: emotional or psychological trauma, deep skin burn, severe friction, severe chronic allergy, chemical intoxication, etc. Always severe!

UNTRIGGER: If vitiligo has been triggered, it can spread at any time. You have to untrigger it. Untriggering is different from achieving the cure. Untriggering means to go back to potential NSV level. Anyone can untrigger NSV. However it's necessary to follow a Functional Treatment.

Functional Treatment includes: good diet, detox, life style change, vitamins, anti-fungals, anti-oxidants, trace nutrients, UVB-NB, topical cream ; * all at the same time *

CURE: For NSV sufferers, Cure should mean to go back to NSV potential level by untriggering it and also achieve full repigmentation in all existing white spots. It's possible to achieve the cure, but it's real hard to get full repigmentation in all spots. The reason for that is the fact that white patches (specially old ones) are probably full of a protein called MIA (www.researchforvitiligo.com) that has been generated by the causes above and accumulated for many years, populating the whole patch.

While there is no cream to bind MIA yet, repigmentation has a huge individual component. The best we can do to improve the chance is to favor it following a real Functional Treatment briefly described above.

DISCLAIMER: http://www.vitiligomap.com/disc.html

When I first began trying to fight my vitiligo, I followed an extremely strict anti candida diet along with supplementation. But the vit kept spreading. It wasn't until I started to address my copper toxicity/imbalance that things started to shift. I have an excessive amount of copper that my body is unable to use due to a lack of ceruloplasmin - ceruloplasmin binds to copper so the body can use it. Without ceruloplasmin copper is allowed to accumulate in various tissues and cause damage (oxidative stress), since in it's unbound state it is considered to be a heavy metal. I have severe adrenal fatigue- and when adrenal activity is insufficient, ceruloplasmin synthesis in the liver declines. Adrenal fatigue is caused by chronic stress of course, and excessive stress burns up the body's zinc stores very rapidly. Zinc is a direct copper antagonist - the ideal level of zinc to copper is 8:1 in favor of zinc. A lack of

Fungus and yeast are opportunistic, and only attach themselves to a weakened host. The body uses copper to control the growth of yeasts and fungi. Yeasts and fungi are anaerobic-they ferment sugars for their energy production. So when copper is not available to the body in sufficient quantity, aerobic or normal oxygen-using metabolism is crippled to some degree, while anaerobic metabolism or the fermentation of sugars flourishes in such an environment. See http://drlwilson.com/articles/copper_toxicity_syndrome.htm

I'm typing all this on my phone, so sorry for any typos ;)

Replies

Azr Khatana December 14, 2014 at 9:54am

I have IBS-c and have been referred to a dietitian who has asked me to follow a FODMAP diet.

The diet is helping me as the symptoms have improved but not gone. However, I believe when my digestive system feels 100% fine, then I am sure it will be the first step of fixing the vitiligo problem as all the symptoms are only experienced after eating certain foods.

Provided that I am currently on FODMAP diet I am still experiencing the same symptoms especially growling/rumbling wind but not as severe as before.
- Robot > Azr Khatana December 17, 2014 at 4:18pm
  
  I'm not familiar with FODMAP diet. Are you avoiding gluten?
  - Chris K > Robot December 19, 2014 at 12:41pm
    
    If you do change your diet to something similar to a Candida diet. The first week might be very uncomfortable. In essence, if you have a fungal overgrowth, when it dies it expels cytotoxins into your body. They can disrupt multiple parts of your body.
    
    I had foggy brain, stomach rumbling, gas, severe dehydration, diarrhea, and my vitiligo seemed to spread initially.
    
    After one week or two, I began to feel intense amounts of excess energy and was barely sleeping. I've since felt amazing approximately 9 months later and have been eating more normally with very few symptoms.
    - Tawny > Chris K December 20, 2014 at 4:35am
      
      When I first began trying to fight my vitiligo, I followed an extremely strict anti candida diet along with supplementation. But the vit kept spreading. It wasn't until I started to address my copper toxicity/imbalance that things started to shift. I have an excessive amount of copper that my body is unable to use due to a lack of ceruloplasmin - ceruloplasmin binds to copper so the body can use it. Without ceruloplasmin copper is allowed to accumulate in various tissues and cause damage (oxidative stress), since in it's unbound state it is considered to be a heavy metal. I have severe adrenal fatigue- and when adrenal activity is insufficient, ceruloplasmin synthesis in the liver declines. Adrenal fatigue is caused by chronic stress of course, and excessive stress burns up the body's zinc stores very rapidly. Zinc is a direct copper antagonist - the ideal level of zinc to copper is 8:1 in favor of zinc. A lack of
      
      Fungus and yeast are opportunistic, and only attach themselves to a weakened host. The body uses copper to control the growth of yeasts and fungi. Yeasts and fungi are anaerobic-they ferment sugars for their energy production. So when copper is not available to the body in sufficient quantity, aerobic or normal oxygen-using metabolism is crippled to some degree, while anaerobic metabolism or the fermentation of sugars flourishes in such an environment. See http://drlwilson.com/articles/copper_toxicity_syndrome.htm
      
      I'm typing all this on my phone, so sorry for any typos ;)
      - Chris K > Tawny December 20, 2014 at 5:04am
        
        Very interesting. Thanks Tawny.
Chris K December 14, 2014 at 6:53am

Very great systematic approach Flavio. I agree 100%.

I do hope that one single link exists and all of this fall into a simple order. It would then allow the medical community to focus and target a single item. For now, this is absolutely the approach to take.
- Robot > Chris K December 14, 2014 at 7:51am
  
  It's getting clearer day after day...
  
  Your anti-fungal approach has added value a lot to me. I used to consider this less relevant that it really seems to be.
  
  Thanks.

This reply was deleted.