Methylation and Vitiligo

I just now remembered about Ms. Sarah Cooper who was the first person I talked to here when I joined www.vitiligofriends.org. It's hard to exactly remember what we discussed then but I remember we talked something about 'methylation'. The last words she said to me before she signed off permanently from this website were something like - "Saurabh, Vitiligo is caused due to improper methylation you are wasting your time discussing and doing things without addressing the primary cause". She left saying this never to be seen again and I too did not pay much attention to it as I heard the word 'methylation' for the first time. Even though she is not a member of this site anymore. One of the discussion started by her on the subject is still there- http://www.vitiligofriends.org/forum/topics/dna-test-reveals-vitiligo-mutations-anyone-have-done-this-test?commentId=690521%3AComment%3A347260 After remembering about this I came across the blog of TheVitiligoGirl who also seems to support her theory on improper methylation - http://realvitiligotreatment.com/paleo-diet-mthfr-mutation-and-vitiligo/ And then a few papers by the experts supporting that there is improper methylation in people having Vitiligo- https://www.ncbi.nlm.nih.gov/m/pubmed/20560952/#fft https://www.aad.org/eposters/Submissions/getFile.aspx?id=958&type=sub Regarding MTHFR gene mutation in Vitiligo - https://www.ncbi.nlm.nih.gov/m/pubmed/24472005/ http://abacupuncture.com.au/uncategorized/mthfr-gene-mutation-what-does-it-mean https://mthfrgenehealth.com/mthfr-conditions/ So, what can we do about it- Is TMG, MSM and Supplements the answer? http://www.organicsulfur4health.com/2016/03/05/why-not-take-sulfur-instead-of-msm/ http://www.jillcarnahan.com/2013/05/12/mthfr-gene-mutation-whats-the-big-deal-about-methylation/ http://www.heartfixer.com/AMRI-Nutrigenomics.htm#CBS

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  • I do remember that. 

    After this post I started researching vitiligo vs 23andme DNA test.  I did not find consistent / evident correlation between them, although I agree that the primary vitiligo cause is genetic (DNA formation / mutation / methylation ).

    Currently, there is nothing we can do to address this primary cause directly.  Supplementation is a possible way to affect the intracelular deficiencies in a long term.  Vitamin E and Quercetin might be a good support to cell adhesion itself.  That's why I advocate a comprehensive supplementation.

    While one can only address the primary cause indirectly, the secondary causes (oxidative stress, friction, stress hormones) can be directly addressed as we have discussed in many threads.  And the fact that the Primary Cause exists, it's not a reason to give up treatments.

    The best answer for your question has already been answered by you:  Comprehensive Supplementation.

    Cheers.

    • Thanks Flavio for your reply.
      I saw your reply to the original discussion.
      I wanted to find out whether I can take ginkgo and Msm complex supplements together. So was researching a bit and then found out about 'methylation' and remembered what Sarah was saying.
      I cannot take Ginkgo and Msm together is the conclusion. Because their side effects are similar. So will alternate with Ginkgo for 3 months and then Msm for there months, like that. May also think of stopping Ginkgo altogether if I don't see much difference.
      But have to take them and try it as I have already purchased both of them for 3 months.

      See what I gather from above papers is that absorption of the supplements by the body is very important and Msm and TMG aid that and helps not only in Vitiligo but also other autoimmune conditions we may be suffering from.
      Taking Msm or TMG would in turn depend upon the sources from which they are obtained. If you are not allergic to those sources you can take either one of them at a low dose.
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