Dear Friends,
I will probably have a meeting (in person) with Dr. Matteo Bordignon this weekend.
I would love to include interesting topics in the meeting assignment.
Please feel free to suggest some.
Regards,
Flavio
You need to be a member of Vitiligo Friends to add comments!
Replies
Hi again Flavio,
Some more thoughts and questions below.
So in your opinion this would work in all body patches even hands?
I'm sceptical because some treatments work in some people others don't. Also some body parts are easier to treat. We know this already just saying.
Also I don't understand why it's difficult to fund him if as you say ''he was able to find the real direct cause of vitiligo and how to bind/inhibit MIA through a cream''. That for me looks like a great breakthrough and if this works will sell like crazy.
They are not convinced maybe?
As I understand Dr. Bordingon doesn't believe that it's an auto immune disease?
If it's not then wouldn't be easier to fiind a cure?
Thanks
It's a complicated issue.
Researches want to find the cure. Some of them for money, some other for recognition only. The problem is that they don't want to work together. They want to be the "one" who found it! Because of that, they don't support each other They work in clusters. Independently.
There are exceptions, of course, and Dr. Matteo's team is clearly one of this.
The lab that was considering to produce his cream submitted a request (properly authorized by him) to another research team, to validate MIA existence.
Guess what happened?
The other research team found the presence of MIA protein in the patches. However, they said that it was not found in 100% of the cases.
Dr. Matteo replied saying that the biopsy should have collected the epidermis from the patch border, not from inside, since MIA spreads out looking for fragile melanocytes. It doesn't remain inside the patch.
If it had been done properly, the MIA presence would have been 100%.
So now, the lab is asking for an animal model, like the one that Le Poole paid for, when they ordered genetically modified mice. The mice was born with white patches, and then they reverted it. The mice did not have vitiligo, buy white spots generated genetically by a cause that they suspect and claim that is the real vitiligo cause.
Regarding auto immune disease related to vitiligo, the immune system (IMS) is the victim (not the villain). It's attracted by the fight between MIA and melanocyte roots (integrins). Microinflammation stays around, what confuses researchers that IMS is the bad guy. I agree that keeping IMS away (with Corticosteroids), gives more chance to melanocytes to remain there, since while IMS is there trying to calm down the microinflammation, it may speed up the detachment... That's the only connection between vitiligo and IMS.
I wish all the reseach teams could work together as one only.
Last but not least, he needs at least US$ 200k fund to continue his research. He spent all his personal money into this. For passion. For reconigtion. He is almost there, despite all the pessimism from other researchers.
Please help him to raise funds, if you can.
Regards.
So, It is quite likely that Dr Bordignon will no succeed
Not really. He has applied for some International European Funds. It may take a year to get an approval.
In the meantime, we can do our part crowdfunding (check the link bellow).
http://www.gofundme.com/5n5n8zuthg8
Hi Flavio,
Do you believe that this treatment would be only a topical cream?
How it would act if you can explain please?
Thanks
Yes. Definitely a cream. The cream will bind/inhibt the MIA protein. It will remove MIA.
Then, melanocytes will populate the patch and migrate from the border (without MIA), decreasing it's size.
Hiya, can you ask him about vitiligo on the lips, i have been told it's very hard to treat because their is no hair. Also i have been told if you have semi permanent makeup, your vitiligo has to be stable. How would you know if it's stable, yes it may stop for one year, but may start again the next year.
Thanks
Flavio
The stability concept is really contradictory.
Usually Doctors say that stability means when vitiligo is not spreading for over a year.
In my opinion, stability is reached when you follow a Funtional Treatment, and stop the major causes (friction/traumas, oxidative stress, and stress hormones), and after that vitiligo stops spreading for over a year.
The fact that there aren't hair follicles in there is something that makes this area more susceptible to vitiligo indeed, but the real problem is that MIA is in there now. So, even if you populate the patch with melanocytes, it's not garanteed that they will remain there. You have to remove MIA from there.
and how can you remove Mia? actually it's not possible?
Good question.
While Dr. is trying to develop a cream to bind it, I'm working on some trials...
I have a hunch that if we could remove the whole vitiligo patch's epidermis (around 0.12mm deep), and then do intensive phototherapy, it might work. In the hands and feet, the epidermis is thicker (around 1mm).
The removal can be with blister, liquid nitrogen or laser CO2.
Imagine that the patch is the shape in black. The epidermis removal should go 3mm farther from the patch bounderies (dashed brown line), because MIA (in red) is in the border trying to expand the patch by detaching melanocytes.
Just a guess. Don't do it, since there is also a risk to increase the patch because of the physical trauma.
Disclaimer
Content available above is for informational purposes only and is not a substitute for professional medical advice. Only your healthcare provider should diagnose your health problems and prescribe a treatment. Your reliance upon whatsoever obtained by you at or through this post is solely at your own risk. The statements made above have not been evaluated by the Food and Drug Administration (FDA).
-
1
-
2
-
3
-
4
of 4 Next