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Hi Friends,

 I'd like to share with you some thoughts.

First of all, * from the web*:

Functional Medicine addresses the underlying causes of disease, using a systems-oriented approach and engaging both patient and practitioner in a therapeutic partnership. It is an evolution in the practice of medicine that better addresses the healthcare needs of the 21st century. By shifting the traditional disease-centered focus of medical practice to a more patient-centered approach, functional medicine addresses the whole person, not just an isolated set of symptoms. Functional medicine practitioners spend time with their patients, listening to their histories and looking at the interactions among genetic, environmental, and lifestyle factors that can influence long-term health and complex, chronic disease. In this way, functional medicine supports the unique expression of health and vitality for each individual. 

Based on the Functional Medicine concept above,  I've been supporting the Functional Treatment theory regarding vitiligo.  Functional Treatment includes: good diet, detox, life style change, vitamins, minerals, anti-oxidants, trace  nutrients, UVB-NB, topical  cream ; * ALL AT THE SAME TIME * to cover all main likely causes.

Please see below why "some treatments" (if not Functional) may have different results in different people:

Example 1) Two persons follow an UVB-NB + Topical Protopic treatment

Result: one person achieves repigmentation, but not the other.

Possible explanation: Although UVB-NB helps a lot melanocyte adhesion, as well as, Protopic provides a big help as a corticosteroid,  maybe the person who didn't achieve any repigmentation has oxidative stress.  It's known that oxidative stress causes defect in the membrane integrity, also causes lipid peroxidation, generates hydrogen peroxide in the skin and mutates mitochondrial DNA.  So, it could explain easily why this treatment worked for just one of the persons.

Example 2) Two persons follow an UVB-NB + Pseudocatalase treatment

Result: one person achieves repigmentation, but not the other.

Possible explanation: Although UVB-NB helps a lot melanocyte adhesion, as well as Pseudocatalase fixes local oxidative stress breaking H2O2,   maybe the person who didn't achieve any repigmentation has a serious dysbiosis ( parasites, fungus, yeast, or any other gut issue) that generates ROS (Reactive oxygen species)  all the time, making impossible a topical pseudocatalase have its anti-oxidant effects.   So, it could explain easily why this treatment worked for just one of the persons.

More examples?  We can think of 200 more examples easily.  We can also include life style, lack of vitamins, lack of trace nutrients, poor diet, food allergy,  adrenal fatigue, heavy metal toxicity as a component that would increase geometrically the number of possibilities.

So, in order to fight vitiligo properly,  covering as much as possible the likely and known causes,  please consider a * Functional Treatment * ( good diet, detox, life style change, vitamins, anti-oxidants, trace  nutrients, UVB-NB, topical  cream ; * ALL AT THE SAME TIME *).

Cheers.