Hi Marie, Thank you for your information about Xcimer and Pesudocatalase, these are new concepts for me. Today I went to the dermatologist and requested NB-UVB, he said I need Xcimer because I am now only focus on my face (a couple of spots) than the whole body. I might try Xcimer next month.
Vitiligo treatment is a procedure to make your body back to balance. Traditional Chinese Medicine focus on that to wake up human body inner balance.It has good effect. You can have a try.
Hello, I’ve tried everything from clinical and home UVB therapy over the past 6 years with various steroid topicals, novitil, protopic and calciprotriene, to oral steroids with no success. Since UVB exposes healthy as well as depigmented areas to the UV rays, I experienced darkening of the healthy skin to the point of hyperpigmentation, which made the depigmented areas more prominent. Using sunscreen on the healthy areas before UVB exposure did nothing to prevent tanning of healthy areas either.
I am now getting Xcimer laser treatment, which pinpoints each spot so that only the vitiligo spot is exposed to the UV rays. After 2 months and 16 treatments, I am starting to see repigmentation in my forearms, torso and pubic area. Xcimer has also been successful in repigmenting difficult areas such as the hands and feet, where UVA and UVB have not been as successful.
I have also been researching a topical that has an increased the success rate not only with repigmentation, but also with arresting the progression of the condition, and that is pseudocatalase cream. There are many research studies on pseudocatalase with light therapy. I’ve pasted one abstract from Pub Med below, but you can do a search for “pseudocatalase and vitiligo” on Pub Med for more articles. <http://www.ncbi.nlm.nih.gov/pubmed>
Most of the research states that in order to get the best results, one needs to purchase the original formula of pseudocatalase which was developed in Greidswald, Germany or the University of Bradford, UK. If you are in the US, you can get a cosmetic grade of pseudocatalase from www.pseudocatalase.com. There are reports of success with the cosmetic grade formula as well. I am going to order this cosmetic grade and will post again if I find it helps in arresting the progression of the vitiligo.
Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short-term UVB exposure: a case study on 33 patients.
Thirty-three patients with the depigmentation disorder vitiligo were successfully treated with a new topical application of pseudocatalase, calcium and short-term UVB light exposure. First repigmentation occurred in the majority of cases after 2-4 months. Complete repigmentation on the face and dorsum of the hands appeared in 90% of the group. In all patients, active depigmentation was arrested. None of them developed new lesions during treatment. No recurrence of the disease was observed during a 2-year follow-up. The rationale for this pilot study originated from a recent understanding of vitiligo at the molecular level. The involved epidermis produces hydrogen peroxide due to defective tetrahydrobiopterin recycling and increased monoamine oxidase A activity, whereupon catalase is inactivated. In addition, calcium homeostasis is perturbed in the affected skin. The substitution for insufficient catalase by a pseudocatalase together with calcium and UVB exposure lead to effective repigmentation.
You are on the right track I absolutely agree with you. I can teach you how to produce your own pseudocatalase, if you want it (becames very afordable and available).
You also have to decrease oxidative stress level with ALA+L-Methionine+L-Glutamine.
Also reduce Lipid peroxidation with Vitamin E.
Additionally take Complex-B (B12, B6, Folate, etc.), Fissh Oil, Probiotics and Zinc.
Last, but the most important advice, avoid friction, trauma and injuries.
Put items 2, 3, 4 and 5 together. Mix it and wait 15 minutes.
After waiting, mix it very well with 100g of VaniCream .
Put in a small bottle and keep in the refrigerator.
You can test your product putting a few drops of a drugstore hydrogen peroxide on a plate. Then you throw a drop of your cream on it and wait a few minutes. The result has to be similar to the following:
Thanks for the information and the links. I certainly would appreciate the information on how to make the pseudocatalase cream.
Interesting you mention the trauma and oxidative stress as a factor in causing vitiligo to activate and spread. I noticed a direct correlation between the onset of my case of non-seg. vitiligo and a bad reaction to a depilatory cream.The exact area that was inflamed from the depilatory cream began to depigment straight away. I thought it was the cream that had temporarily bleached the skin, but it stayed and has spread everywhere. However, every doctor I have spoken to denies that inflammatory skin reaction, food allergies, or other sorts of trauma to skin have anything to do with it. Yet, I keep seeing a pattern as the spots spread, and it seems it is always after some sort of oxidative stress. I'm glad to read that you and others see the same patterns and have some good suggestions to combat the progression.
Marie, Doctors don't know much about this disease.
In NSV, when you have an itch, or allergy, or inflamation, or injury, or sun burn, etc. on skin and the vitiligo appears, it was not the vitiligo that caused the problem, but the problem caused vitiligo.
I know people that had itches because of dry skin and the itches caused vitiligo.
Besides, friction plays a major role in the development of this disease. The reason for that is the following: According Dr. Matteo Bordignon, an Italian researcher, all this physical traumas (friction, injuries, itches, sun burns, allergies, inflammations, etc.) stimulate melanocytes to produce MIA (melanoma inhibitor activity) protein. This protein is designed to detach the own melanocyte from the basal membrane, destroying the integrin that links both. So melanocytes exfoliate in the epidermis. No immune system action is required, as doctors usually say.
Of course that non vitiligo sufferers don't generate this protein, unless they have real melanoma (skin cancer), which is not the case. Vitiligo sufferers have the predisposition to generate it wrongly, so that it self detaches good melanocites. That's the genetic explanation.
The only way to cure the white spots is removing MIA from there. Some products do it poorly, like Protopic and Elidel. We were told that these products suppress the immune system. It might be true, but it's not the reason for their poor help. UVB-NB is also good to strength the integrin that links melanocytes to the basal membrane.
So last, but not least, Dr. Matteo Bordignon (www.researchforvitiligo.com) will come up very soon with a cream that renders MIA, then allowing melanocytes to reproduce and stay attached to the basal membrane, producing melanin as their main function, performing the dendrite, and giving our color back.
Replies
Vitiligo treatment is a procedure to make your body back to balance. Traditional Chinese Medicine focus on that to wake up human body inner balance.It has good effect. You can have a try.
Hello, I’ve tried everything from clinical and home UVB therapy over the past 6 years with various steroid topicals, novitil, protopic and calciprotriene, to oral steroids with no success. Since UVB exposes healthy as well as depigmented areas to the UV rays, I experienced darkening of the healthy skin to the point of hyperpigmentation, which made the depigmented areas more prominent. Using sunscreen on the healthy areas before UVB exposure did nothing to prevent tanning of healthy areas either.
I am now getting Xcimer laser treatment, which pinpoints each spot so that only the vitiligo spot is exposed to the UV rays. After 2 months and 16 treatments, I am starting to see repigmentation in my forearms, torso and pubic area. Xcimer has also been successful in repigmenting difficult areas such as the hands and feet, where UVA and UVB have not been as successful.
I have also been researching a topical that has an increased the success rate not only with repigmentation, but also with arresting the progression of the condition, and that is pseudocatalase cream. There are many research studies on pseudocatalase with light therapy. I’ve pasted one abstract from Pub Med below, but you can do a search for “pseudocatalase and vitiligo” on Pub Med for more articles. <http://www.ncbi.nlm.nih.gov/pubmed>
Most of the research states that in order to get the best results, one needs to purchase the original formula of pseudocatalase which was developed in Greidswald, Germany or the University of Bradford, UK. If you are in the US, you can get a cosmetic grade of pseudocatalase from www.pseudocatalase.com. There are reports of success with the cosmetic grade formula as well. I am going to order this cosmetic grade and will post again if I find it helps in arresting the progression of the vitiligo.
Treatment of vitiligo with a topical application of pseudocatalase and calcium in combination with short-term UVB exposure: a case study on 33 patients.
Schallreuter KU1, Wood JM, Lemke KR, Levenig C.
Author information
Abstract
Thirty-three patients with the depigmentation disorder vitiligo were successfully treated with a new topical application of pseudocatalase, calcium and short-term UVB light exposure. First repigmentation occurred in the majority of cases after 2-4 months. Complete repigmentation on the face and dorsum of the hands appeared in 90% of the group. In all patients, active depigmentation was arrested. None of them developed new lesions during treatment. No recurrence of the disease was observed during a 2-year follow-up. The rationale for this pilot study originated from a recent understanding of vitiligo at the molecular level. The involved epidermis produces hydrogen peroxide due to defective tetrahydrobiopterin recycling and increased monoamine oxidase A activity, whereupon catalase is inactivated. In addition, calcium homeostasis is perturbed in the affected skin. The substitution for insufficient catalase by a pseudocatalase together with calcium and UVB exposure lead to effective repigmentation.
PC-KUS.pdf
You are on the right track I absolutely agree with you. I can teach you how to produce your own pseudocatalase, if you want it (becames very afordable and available).
You also have to decrease oxidative stress level with ALA+L-Methionine+L-Glutamine.
Also reduce Lipid peroxidation with Vitamin E.
Additionally take Complex-B (B12, B6, Folate, etc.), Fissh Oil, Probiotics and Zinc.
Last, but the most important advice, avoid friction, trauma and injuries.
http://www.vitiligofriends.org/forum/topics/mandatory-reading-for-a...
Check this product too:
http://www.amazon.com/gp/product/B008BASLD4/ref=oh_aui_detailpage_o...
To produce 100 grams of the pseudocatalase cream you need:
1- A precision scale ( http://www.ebay.co.uk/itm/Double-Precision-0-01g-x-100g-0-1g-x-500g... )
2- 380mg (0.38g) of Manganese (II) Chloride ( http://www.ebay.com/itm/Manganese-II-Chloride-Tetrahydrate-ACS-99-4... )
3- 200mg (0.2g) of Calcium Chloride ( http://www.amazon.com/dp/B00I53ZG1W/ref=pe_385040_30332220_pe_33455... )
4- 2.3g of Sodium Bicarbonate (Baking Soda) ( http://www.amazon.com/dp/B005JHF428/ref=pe_385040_30332200_TE_item )
5- Three drops of distilled water (buy in Walmart)
6- 100g of VaniCream ( http://www.amazon.com/Vanicream-Moisturizing-Skin-Cream-Ounces/dp/B... )
Put items 2, 3, 4 and 5 together. Mix it and wait 15 minutes.
After waiting, mix it very well with 100g of VaniCream .
Put in a small bottle and keep in the refrigerator.
You can test your product putting a few drops of a drugstore hydrogen peroxide on a plate. Then you throw a drop of your cream on it and wait a few minutes. The result has to be similar to the following:
Thanks for the information and the links. I certainly would appreciate the information on how to make the pseudocatalase cream.
Interesting you mention the trauma and oxidative stress as a factor in causing vitiligo to activate and spread. I noticed a direct correlation between the onset of my case of non-seg. vitiligo and a bad reaction to a depilatory cream.The exact area that was inflamed from the depilatory cream began to depigment straight away. I thought it was the cream that had temporarily bleached the skin, but it stayed and has spread everywhere. However, every doctor I have spoken to denies that inflammatory skin reaction, food allergies, or other sorts of trauma to skin have anything to do with it. Yet, I keep seeing a pattern as the spots spread, and it seems it is always after some sort of oxidative stress. I'm glad to read that you and others see the same patterns and have some good suggestions to combat the progression.
Marie, Doctors don't know much about this disease.
In NSV, when you have an itch, or allergy, or inflamation, or injury, or sun burn, etc. on skin and the vitiligo appears, it was not the vitiligo that caused the problem, but the problem caused vitiligo.
I know people that had itches because of dry skin and the itches caused vitiligo.
Besides, friction plays a major role in the development of this disease. The reason for that is the following: According Dr. Matteo Bordignon, an Italian researcher, all this physical traumas (friction, injuries, itches, sun burns, allergies, inflammations, etc.) stimulate melanocytes to produce MIA (melanoma inhibitor activity) protein. This protein is designed to detach the own melanocyte from the basal membrane, destroying the integrin that links both. So melanocytes exfoliate in the epidermis. No immune system action is required, as doctors usually say.
Of course that non vitiligo sufferers don't generate this protein, unless they have real melanoma (skin cancer), which is not the case. Vitiligo sufferers have the predisposition to generate it wrongly, so that it self detaches good melanocites. That's the genetic explanation.
The only way to cure the white spots is removing MIA from there. Some products do it poorly, like Protopic and Elidel. We were told that these products suppress the immune system. It might be true, but it's not the reason for their poor help. UVB-NB is also good to strength the integrin that links melanocytes to the basal membrane.
So last, but not least, Dr. Matteo Bordignon (www.researchforvitiligo.com) will come up very soon with a cream that renders MIA, then allowing melanocytes to reproduce and stay attached to the basal membrane, producing melanin as their main function, performing the dendrite, and giving our color back.